Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Triabin and Activation peptide fragment 2 (preferred)
PDBe Complex ID:
PDB-CPX-133174 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain
Molecule details ›
Chain: L
Length: 41 amino acids
Theoretical weight: 4.79 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Thrombin light chain
Structure domains: Thrombin light chain domain
Length: 41 amino acids
Theoretical weight: 4.79 KDa
Source organism: Bos taurus
UniProt:
- Canonical:
P00735 (Residues: 326-366; Coverage: 7%)
Sequence domains: Thrombin light chain
Structure domains: Thrombin light chain domain
Thrombin heavy chain
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P00735 (Residues: 367-625; Coverage: 43%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Triabin
Molecule details ›
Chain: I
Length: 142 amino acids
Theoretical weight: 16.04 KDa
Source organism: Meccus pallidipennis
Expression system: INSECT CELLS
UniProt:
Structure domains: Lipocalin
Length: 142 amino acids
Theoretical weight: 16.04 KDa
Source organism: Meccus pallidipennis
Expression system: INSECT CELLS
UniProt:
- Canonical: Q27049 (Residues: 19-160; Coverage: 100%)
Structure domains: Lipocalin
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU RUH2R
Spacegroup:
P212121
Expression system: INSECT CELLS
