› 1aww

Solution NMR

SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, 42 STRUCTURES

Released:
DOI: 10.2210/pdb1aww/pdb
PDB entry 1aww coloured by chain, ensemble of 42 models, front view.
PDB entry 1aww coloured by chain, ensemble of 42 models, side view.
PDB entry 1aww coloured by chain, ensemble of 42 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the SH3 domain from Bruton's tyrosine kinase.
Hansson H, Mattsson PT, Allard P, Haapaniemi P, Vihinen M, Smith CI, Hard T
Biochemistry 37 2912-24 (1998)
PMID: 9485443

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase BTK Chain: A
Molecule details ›
Chain: A
Length: 67 amino acids
Theoretical weight: 7.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06187 (Residues: 211-275; Coverage: 10%)
Gene names: AGMX1, ATK, BPK, BTK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: AB INITIO-SIMULATED ANNEALING
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Tec family kinases in T lymphocyte development and function.
Berg et al. (2005)
8 more

2 mentions without citation

The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.
Crofford et al. (2016)
1 more