› 1axm

X-ray diffraction
3Å resolution

HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR

Released:
DOI: 10.2210/pdb1axm/pdb
PDB entry 1axm coloured by chain, front view.
PDB entry 1axm coloured by chain, side view.
PDB entry 1axm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
DiGabriele AD, Lax I, Chen DI, Svahn CM, Jaye M, Schlessinger J, Hendrickson WA
Nature 393 812-7 (1998)
PMID: 9655399

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138608 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Fibroblast growth factor 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 135 amino acids
Theoretical weight: 15.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05230 (Residues: 21-155; Coverage: 87%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

Carbohydrate polymer : NEW Components: SGN, IDS
Carbohydrate polymer
Carbohydrate polymer : NEW Components: SGN, IDS
Carbohydrate polymer
No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2221
Unit cell:
a: 87.69Å b: 158.05Å c: 190.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.304
Expression system: Escherichia coli

Quick links

Citations

37 review citations

Met, metastasis, motility and more.
Birchmeier et al. (2003)
36 more

18 mentions without citation

Demystifying heparan sulfate-protein interactions.
Xu et al. (2014)
17 more