› 1b2t

Solution NMR

SOLUTION STRUCTURE OF THE CX3C CHEMOKINE DOMAIN OF FRACTALKINE

Released:
DOI: 10.2210/pdb1b2t/pdb
PDB entry 1b2t coloured by chain, ensemble of 20 models, front view.
PDB entry 1b2t coloured by chain, ensemble of 20 models, side view.
PDB entry 1b2t coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1.
Mizoue LS, Bazan JF, Johnson EC, Handel TM
Biochemistry 38 1402-14 (1999)
PMID: 9931005

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160266 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Processed fractalkine Chain: A
Molecule details ›
Chain: A
Length: 77 amino acids
Theoretical weight: 8.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78423 (Residues: 25-100; Coverage: 20%)
Gene names: A-152E5.2, CX3CL1, FKN, NTT, SCYD1
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: RESTRAINED MOLECULAR DYNAMICS-SIMULATED ANNEALING COUPLED WITH THE AMBIGUOUS RESTRAINTS FOR ITERATIVE ASSIGNMENT (ARIA) EXTENSION OF NILGES (M.NILGES, J. MOL. BIOL. 245, 645-660, 1995).
Expression system: Escherichia coli

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Citations

26 review citations

Chemokine: receptor structure, interactions, and antagonism.
Allen et al. (2007)
25 more

5 mentions without citation

Search for allosteric disulfide bonds in NMR structures.
Schmidt et al. (2007)
4 more