Function and Biology

RAT LIVER S-ADENOSYLHOMOCYSTEIN HYDROLASE

Source organism: Rattus norvegicus
Biochemical function: adenosylselenohomocysteinase activity
Biological process: circadian sleep/wake cycle
Cellular component: melanosome

Sequence families

Pfam Protein families (Pfam)
PF05221
Domain description: S-adenosyl-L-homocysteine hydrolase
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 1b3r contains 8 copies of Pfam domain PF05221 (S-adenosyl-L-homocysteine hydrolase) in Adenosylhomocysteinase. Showing 2 copies in chain A.

PF00670
Domain description: S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 1b3r contains 4 copies of Pfam domain PF00670 (S-adenosyl-L-homocysteine hydrolase, NAD binding domain) in Adenosylhomocysteinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000043
Domain description: Adenosylhomocysteinase-like
Occurring in:
  1. Adenosylhomocysteinase
IPR042172
Domain description: Adenosylhomocysteinase-like superfamily
Occurring in:
  1. Adenosylhomocysteinase
IPR020082
Domain description: S-adenosyl-L-homocysteine hydrolase, conserved site
Occurring in:
  1. Adenosylhomocysteinase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Adenosylhomocysteinase
IPR015878
Domain description: S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Occurring in:
  1. Adenosylhomocysteinase

Structure domains

CATH CATH domains
3.40.50.1480
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Adenosylhomocysteinase-like
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 1b3r contains 4 copies of CATH domain 3.40.50.1480 (Rossmann fold) in Adenosylhomocysteinase. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 1b3r contains 4 copies of CATH domain 3.40.50.720 (Rossmann fold) in Adenosylhomocysteinase. Showing 1 copy in chain A.
SCOP SCOP annotations
52300
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: Formate/glycerate dehydrogenase catalytic domain-like
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 1b3r contains 4 copies of SCOP domain 52300 (S-adenosylhomocystein hydrolase) in Adenosylhomocysteinase. Showing 1 copy in chain A.
51830
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 1b3r contains 4 copies of SCOP domain 51830 (Formate/glycerate dehydrogenases, NAD-domain) in Adenosylhomocysteinase. Showing 1 copy in chain A.