› 1b8m

X-ray diffraction
2.75Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150010 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Brain-derived neurotrophic factor Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23560 (Residues: 129-247; Coverage: 52%)
Gene name: BDNF
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines
Neurotrophin-4 Chain: B
Molecule details ›
Chain: B
Length: 130 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P34130 (Residues: 81-210; Coverage: 70%)
Gene names: NTF4, NTF5
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P21212
Unit cell:
a: 50.7Å b: 105.9Å c: 51.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.279
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Neurotrophins: roles in neuronal development and function.
Huang et al. (2001)
9 more

19 mentions without citation

Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness.
Khalin et al. (2015)
18 more