› 1ba4

Solution NMR

THE SOLUTION STRUCTURE OF AMYLOID BETA-PEPTIDE (1-40) IN A WATER-MICELLE ENVIRONMENT. IS THE MEMBRANE-SPANNING DOMAIN WHERE WE THINK IT IS? NMR, 10 STRUCTURES

Released:
DOI: 10.2210/pdb1ba4/pdb
PDB entry 1ba4 coloured by chain, ensemble of 10 models, front view.
PDB entry 1ba4 coloured by chain, ensemble of 10 models, side view.
PDB entry 1ba4 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?
Coles M, Bicknell W, Watson AA, Fairlie DP, Craik DJ
Biochemistry 37 11064-77 (1998)
PMID: 9693002

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chain: A
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
Expression system: unidentified
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)
Structure domains: Amyloidogenic glycoprotein, amyloid-beta peptide

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING USING NOE DISTANCE CONSTRAINTS
Expression system: unidentified

Quick links

Citations

38 review citations

Alzheimer's amyloid fibrils: structure and assembly.
Serpell LC. (2000)
37 more

55 mentions without citation

Amyloid beta: structure, biology and structure-based therapeutic development.
Chen et al. (2017)
54 more