› 1ba6

Solution NMR

SOLUTION STRUCTURE OF THE METHIONINE-OXIDIZED AMYLOID BETA-PEPTIDE (1-40). DOES OXIDATION AFFECT CONFORMATIONAL SWITCHING? NMR, 10 STRUCTURES

Released:
DOI: 10.2210/pdb1ba6/pdb
PDB entry 1ba6 coloured by chain, ensemble of 10 models, front view.
PDB entry 1ba6 coloured by chain, ensemble of 10 models, side view.
PDB entry 1ba6 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of methionine-oxidized amyloid beta-peptide (1-40). Does oxidation affect conformational switching?
Watson AA, Fairlie DP, Craik DJ
Biochemistry 37 12700-6 (1998)
PMID: 9737846

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chain: A
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.35 KDa
Source organism: Homo sapiens
Expression system: unidentified
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SME 1 x SME

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING USING NOE DISTANCE CONSTRAINTS
Expression system: unidentified

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Citations

9 review citations

Alzheimer's amyloid fibrils: structure and assembly.
Serpell LC. (2000)
8 more

8 mentions without citation

Amyloid beta: structure, biology and structure-based therapeutic development.
Chen et al. (2017)
7 more