› 1bff

X-ray diffraction
2Å resolution

THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR

Released:
DOI: 10.2210/pdb1bff/pdb
PDB entry 1bff coloured by chain, front view.
PDB entry 1bff coloured by chain, side view.
PDB entry 1bff coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray structure of the 154-amino-acid form of recombinant human basic fibroblast growth factor. comparison with the truncated 146-amino-acid form.
Kastrup JS, Eriksson ES, Dalbøge H, Flodgaard H
Acta Crystallogr D Biol Crystallogr 53 160-8 (1997)
PMID: 15299950

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140533 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 2 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09038 (Residues: 160-288; Coverage: 45%)
Gene names: FGF2, FGFB
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

2 bound ligands:
Ligand PO4 1 x PO4
Ligand BME 1 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P1
Unit cell:
a: 30.8Å b: 33.3Å c: 36.5Å
α: 64.1° β: 73° γ: 76.1°
R-values:
R R work R free
0.19 0.19 not available
Expression system: Escherichia coli

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Citations

2 review citations

Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells.
Nickel et al. (2008)
1 more

10 mentions without citation

Polyoxometalates as Potential Next-Generation Metallodrugs in the Combat Against Cancer.
Bijelic et al. (2019)
9 more