› 1bg1

X-ray diffraction
2.25Å resolution

TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX

Released:
DOI: 10.2210/pdb1bg1/pdb
PDB entry 1bg1 coloured by chain, front view.
PDB entry 1bg1 coloured by chain, side view.
PDB entry 1bg1 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Three-dimensional structure of the Stat3beta homodimer bound to DNA.
Becker S, Groner B, Müller CW
Nature 394 145-51 (1998)
PMID: 9671298

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113487 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Signal transducer and activator of transcription 3 Chain: A
Molecule details ›
Chain: A
Length: 596 amino acids
Theoretical weight: 68.22 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P42227 (Residues: 127-715; Coverage: 77%)
Gene names: Aprf, Stat3
Sequence domains:
Structure domains:
DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3') Chain: B
Molecule details ›
Chain: B
Length: 18 nucleotides
Theoretical weight: 5.44 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID2
Spacegroup: I41
Unit cell:
a: 174Å b: 174Å c: 79.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.246 0.301
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

99 review citations

Stats: transcriptional control and biological impact.
Levy et al. (2002)
98 more

169 mentions without citation

Molecular docking and structure-based drug design strategies.
Ferreira et al. (2015)
168 more