› 1bg6

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF THE N-(1-D-CARBOXYLETHYL)-L-NORVALINE DEHYDROGENASE FROM ARTHROBACTER SP. STRAIN 1C

Released:
DOI: 10.2210/pdb1bg6/pdb
PDB entry 1bg6 coloured by chain, front view.
PDB entry 1bg6 coloured by chain, side view.
PDB entry 1bg6 coloured by chain, top view.
Source organism: Arthrobacter sp. 1C
Primary publication:
Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase.
Britton KL, Asano Y, Rice DW
Nat Struct Biol 5 593-601 (1998)
PMID: 9665174

Function and Biology Details

Reaction catalysed: 
(2S)-2-((1-(R)-carboxyethyl)amino)pentanoate + NAD(+) + H(2)O = L-2-aminopentanoic acid + pyruvate + NADH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175019 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Opine dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 359 amino acids
Theoretical weight: 37.97 KDa
Source organism: Arthrobacter sp. 1C
Expression system: Escherichia coli
UniProt:
  • Canonical: Q44297 (Residues: 1-359; Coverage: 100%)
Gene name: odh
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: P21212
Unit cell:
a: 104.9Å b: 80Å c: 45.5Å
α: 90° β: 90° γ: 90°
Expression system: Escherichia coli

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Citations

1 review citation

NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application.
Sharma et al. (2017)
15 other articles

6 mentions without citation

A graph-theory algorithm for rapid protein side-chain prediction.
Canutescu et al. (2003)
5 more