› 1bnl

X-ray diffraction
2.9Å resolution

ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN

Released:
DOI: 10.2210/pdb1bnl/pdb
PDB entry 1bnl coloured by chain, front view.
PDB entry 1bnl coloured by chain, side view.
PDB entry 1bnl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Zinc-dependent dimers observed in crystals of human endostatin.
Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC
Proc Natl Acad Sci U S A 95 10443-8 (1998)
PMID: 9724722

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endostatin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 178 amino acids
Theoretical weight: 19.59 KDa
Source organism: Homo sapiens
Expression system: NS/0 MURINE MYELOMA CELLS
UniProt:
  • Canonical: P39060 (Residues: 1572-1749; Coverage: 10%)
Gene name: COL18A1
Sequence domains: Collagenase NC10 and Endostatin
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2
Unit cell:
a: 92.713Å b: 74.266Å c: 137.805Å
α: 90° β: 102.55° γ: 90°
R-values:
R R work R free
0.24 0.24 0.275
Expression system: NS/0 MURINE MYELOMA CELLS

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Citations

20 review citations

Angiogenesis.
Folkman J. (2006)
19 more

8 mentions without citation

Zinc-dependent dimers observed in crystals of human endostatin.
Ding et al. (1998)
7 more