› 1boe

Solution NMR

STRUCTURE OF THE IGF BINDING DOMAIN OF THE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5): IMPLICATIONS FOR IGF AND IGF-I RECEPTOR INTERACTIONS

Released:
DOI: 10.2210/pdb1boe/pdb
PDB entry 1boe coloured by chain, ensemble of 20 models, front view.
PDB entry 1boe coloured by chain, ensemble of 20 models, side view.
PDB entry 1boe coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.
Kalus W, Zweckstetter M, Renner C, Sanchez Y, Georgescu J, Grol M, Demuth D, Schumacher R, Dony C, Lang K, Holak TA
EMBO J 17 6558-72 (1998)
PMID: 9822601

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150254 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor-binding protein 5 Chain: A
Molecule details ›
Chain: A
Length: 47 amino acids
Theoretical weight: 5.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P24593 (Residues: 60-106; Coverage: 19%)
Gene names: IBP5, IGFBP5
Sequence domains: Insulin-like growth factor binding protein
Structure domains: Omega-AgatoxinV

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMUALTED ANNEALING

Quick links

Citations

24 review citations

Cellular actions of the insulin-like growth factor binding proteins.
Firth et al. (2002)
23 more

5 mentions without citation

Defining the pathway to insulin-like growth factor system targeting in cancer.
Rosenzweig et al. (2010)
4 more