› 1bqs

X-ray diffraction
2.2Å resolution

THE CRYSTAL STRUCTURE OF MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MADCAM-1)

Released:
DOI: 10.2210/pdb1bqs/pdb
PDB entry 1bqs coloured by chain, front view.
PDB entry 1bqs coloured by chain, side view.
PDB entry 1bqs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition.
Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH
Structure 6 793-801 (1998)
PMID: 9655832

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171707 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucosal addressin cell adhesion molecule 1 Chain: A
Molecule details ›
Chain: A
Length: 209 amino acids
Theoretical weight: 22.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13477 (Residues: 23-231; Coverage: 57%)
Gene name: MADCAM1
Sequence domains: Adhesion molecule, immunoglobulin-like
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2221
Unit cell:
a: 65.76Å b: 101.1Å c: 70.04Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.28

Quick links

Citations

3 review citations

Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses.
Wang et al. (1998)
2 more

6 mentions without citation

Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome.
Yang et al. (2009)
5 more