› 1br8

X-ray diffraction
2.9Å resolution

IMPLICATIONS FOR FUNCTION AND THERAPY OF A 2.9A STRUCTURE OF BINARY-COMPLEXED ANTITHROMBIN

Released:
DOI: 10.2210/pdb1br8/pdb
PDB entry 1br8 coloured by chain, front view.
PDB entry 1br8 coloured by chain, side view.
PDB entry 1br8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.
Skinner R, Chang WS, Jin L, Pei X, Huntington JA, Abrahams JP, Carrell RW, Lomas DA
J Mol Biol 283 9-14 (1998)
PMID: 9761669

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
hetero trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-133778 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Antithrombin-III Chains: I, L
Molecule details ›
Chains: I, L
Length: 432 amino acids
Theoretical weight: 49.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
PROTEIN (PEPTIDE) Chain: P
Molecule details ›
Chain: P
Length: 12 amino acids
Theoretical weight: 1.09 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX7.2
Spacegroup: P21
Unit cell:
a: 69.12Å b: 101.69Å c: 87.02Å
α: 90° β: 104.36° γ: 90°
R-values:
R R work R free
0.23 not available not available
Expression system: Not provided

Quick links

Citations

12 review citations

Cell surface heparan sulfate and its roles in assisting viral infections.
Liu et al. (2002)
11 more

1 mention without citation

An overview of the serpin superfamily.
Law et al. (2006)