Function and Biology Details
Reaction catalysed:
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Pancreatic trypsin inhibitor Kunitz domain
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin domain
- Pancreatic trypsin inhibitor Kunitz domain superfamily
- Peptidase S1, PA clan, chymotrypsin-like fold
- Proteinase inhibitor I2, Kunitz, conserved site
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
1 more domain
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133399 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Anionic trypsin-2
Molecule details ›
Chain: E
Length: 223 amino acids
Theoretical weight: 23.81 KDa
Source organism: Rattus norvegicus
Expression system: unidentified
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 223 amino acids
Theoretical weight: 23.81 KDa
Source organism: Rattus norvegicus
Expression system: unidentified
UniProt:
- Canonical:
P00763 (Residues: 24-246; Coverage: 97%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Soluble APP-beta
Molecule details ›
Chain: I
Length: 56 amino acids
Theoretical weight: 6.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain
Length: 56 amino acids
Theoretical weight: 6.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P05067 (Residues: 287-342; Coverage: 7%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Spacegroup:
P3221
Expression systems:
- unidentified
- Not provided
