› 1bu8

X-ray diffraction
1.8Å resolution

RAT PANCREATIC LIPASE RELATED PROTEIN 2

Released:
DOI: 10.2210/pdb1bu8/pdb
PDB entry 1bu8 coloured by chain, front view.
PDB entry 1bu8 coloured by chain, side view.
PDB entry 1bu8 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure and activity of rat pancreatic lipase-related protein 2.
Roussel A, Yang Y, Ferrato F, Verger R, Cambillau C, Lowe M
J Biol Chem 273 32121-8 (1998)
PMID: 9822688

Function and Biology Details

Reactions catalysed: 
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H(2)O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pancreatic lipase-related protein 2 Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 50.92 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P54318 (Residues: 17-468; Coverage: 100%)
Gene names: Plrp2, Pnliprp2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE DW32
Spacegroup: P21
Unit cell:
a: 57.393Å b: 79.133Å c: 60.94Å
α: 90° β: 102.07° γ: 90°
R-values:
R R work R free
0.202 0.202 0.244
Expression system: Spodoptera frugiperda

Quick links

Citations

12 review citations

The metabolic serine hydrolases and their functions in mammalian physiology and disease.
Long et al. (2011)
11 more

9 mentions without citation

Current Knowledge on Mammalian Phospholipase A1, Brief History, Structures, Biochemical and Pathophysiological Roles.
Yaginuma et al. (2022)
8 more