› 1c15

Solution NMR

SOLUTION STRUCTURE OF APAF-1 CARD

Released:
DOI: 10.2210/pdb1c15/pdb
PDB entry 1c15 coloured by chain, ensemble of 16 models, front view.
PDB entry 1c15 coloured by chain, ensemble of 16 models, side view.
PDB entry 1c15 coloured by chain, ensemble of 16 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction.
Zhou P, Chou J, Olea RS, Yuan J, Wagner G
Proc Natl Acad Sci U S A 96 11265-70 (1999)
PMID: 10500165

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptotic protease-activating factor 1 Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14727 (Residues: 1-97; Coverage: 8%)
Gene names: APAF1, KIAA0413
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

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Citations

24 review citations

The biochemistry of apoptosis.
Hengartner MO. (2000)
23 more

7 mentions without citation

The PYRIN domain in signal transduction.
Stehlik C. (2007)
6 more