› 1c26

X-ray diffraction
1.7Å resolution

CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN

Released:
DOI: 10.2210/pdb1c26/pdb
PDB entry 1c26 coloured by chain, front view.
PDB entry 1c26 coloured by chain, side view.
PDB entry 1c26 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms.
Jeffrey PD, Gorina S, Pavletich NP
Science 267 1498-502 (1995)
PMID: 7878469

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138138 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chain: A
Molecule details ›
Chain: A
Length: 32 amino acids
Theoretical weight: 3.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 325-356; Coverage: 8%)
Gene names: P53, TP53
Sequence domains: P53 tetramerisation motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P422
Unit cell:
a: 45.45Å b: 45.45Å c: 33.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 not available
Expression system: Escherichia coli

Quick links

Citations

67 review citations

p53, the cellular gatekeeper for growth and division.
Levine AJ. (1997)
66 more

36 mentions without citation

The tumor suppressor p53: from structures to drug discovery.
Joerger et al. (2010)
35 more