› 1c5g

X-ray diffraction
2.6Å resolution

PLASMINOGEN ACTIVATOR INHIBITOR-1

Released:
DOI: 10.2210/pdb1c5g/pdb
PDB entry 1c5g coloured by chain, front view.
PDB entry 1c5g coloured by chain, side view.
PDB entry 1c5g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition.
Tucker HM, Mottonen J, Goldsmith EJ, Gerard RD
Nat Struct Biol 2 442-5 (1995)
PMID: 7664104

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138523 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 402 amino acids
Theoretical weight: 45.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05121 (Residues: 1-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: C2
Unit cell:
a: 157.59Å b: 47.84Å c: 62.88Å
α: 90° β: 107.78° γ: 90°
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance.
Gettins et al. (2016)
6 more

9 mentions without citation

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition.
Sillen et al. (2020)
8 more