› 1cbj

X-ray diffraction
1.65Å resolution

CRYSTAL STRUCTURE OF BOVINE SUPEROXIDE DISMUTASE CRYSTAL.

Released:
DOI: 10.2210/pdb1cbj/pdb
PDB entry 1cbj coloured by chain, front view.
PDB entry 1cbj coloured by chain, side view.
PDB entry 1cbj coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystallographic structures of bovine copper-zinc superoxide dismutase reveal asymmetry in two subunits: functionally important three and five coordinate copper sites captured in the same crystal.
Hough MA, Hasnain SS
J Mol Biol 287 579-92 (1999)
PMID: 10092461

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B
Molecule details ›
Chains: A, B
Length: 151 amino acids
Theoretical weight: 15.57 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00442 (Residues: 2-152; Coverage: 99%)
Gene name: SOD1
Sequence domains: Copper/zinc superoxide dismutase (SODC)
Structure domains: Superoxide dismutase, copper/zinc binding domain

Ligands and Environments

2 bound ligands:
Ligand CU 2 x CU
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P212121
Unit cell:
a: 47.77Å b: 51.13Å c: 147.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.228

Quick links

Citations

4 review citations

Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis.
Valentine et al. (2005)
3 more

19 mentions without citation

Multiscale Estimation of Binding Kinetics Using Brownian Dynamics, Molecular Dynamics and Milestoning.
Votapka et al. (2015)
18 more