› 1ccz

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF THE CD2-BINDING DOMAIN OF CD58 (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3) AT 1.8-A RESOLUTION

Released:
DOI: 10.2210/pdb1ccz/pdb
PDB entry 1ccz coloured by chain, front view.
PDB entry 1ccz coloured by chain, side view.
PDB entry 1ccz coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution.
Ikemizu S, Sparks LM, van der Merwe PA, Harlos K, Stuart DI, Jones EY, Davis SJ
Proc Natl Acad Sci U S A 96 4289-94 (1999)
PMID: 10200255

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lymphocyte function-associated antigen 3; T-cell surface antigen CD2 Chain: A
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 19.94 KDa
Source organisms: Expression system: Cricetulus griseus
UniProt:
  • Canonical: P19256 (Residues: 29-122; Coverage: 42%)
  • Canonical: P08921 (Residues: 122-198; Coverage: 24%)
Gene names: CD58, Cd2, LFA3
Sequence domains: Immunoglobulin C2-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P3221
Unit cell:
a: 116.43Å b: 116.43Å c: 51.52Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.202 0.243
Expression system: Cricetulus griseus

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Citations

11 review citations

Molecular interactions mediating T cell antigen recognition.
van der Merwe et al. (2003)
10 more

18 mentions without citation

CD2 Immunobiology.
Binder et al. (2020)
17 more