› 1cd0

X-ray diffraction
1.9Å resolution

STRUCTURE OF HUMAN LAMDA-6 LIGHT CHAIN DIMER JTO

Released:
DOI: 10.2210/pdb1cd0/pdb
PDB entry 1cd0 coloured by chain, front view.
PDB entry 1cd0 coloured by chain, side view.
PDB entry 1cd0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tertiary structure of human lambda 6 light chains.
Pokkuluri PR, Solomon A, Weiss DT, Stevens FJ, Schiffer M
Amyloid 6 165-71 (1999)
PMID: 10524280

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134496 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin lambda variable 6-57 Chains: A, B
Molecule details ›
Chains: A, B
Length: 111 amino acids
Theoretical weight: 12.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01721 (Residues: 20-117; Coverage: 100%)
Gene name: IGLV6-57
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 42.9Å b: 60.5Å c: 73.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.184 0.24
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Amyloid formation in light chain amyloidosis.
Ramirez-Alvarado M. (2012)
4 more

9 mentions without citation

Systemic amyloidoses.
Blancas-Mejía et al. (2013)
8 more