› 1cde

X-ray diffraction
2.5Å resolution

STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE

Released:
DOI: 10.2210/pdb1cde/pdb
PDB entry 1cde coloured by chain, front view.
PDB entry 1cde coloured by chain, side view.
PDB entry 1cde coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase.
Almassy RJ, Janson CA, Kan CC, Hostomska Z
Proc Natl Acad Sci U S A 89 6114-8 (1992)
PMID: 1631098

Function and Biology Details

Reaction catalysed: 
10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoribosylglycinamide formyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 212 amino acids
Theoretical weight: 23.27 KDa
Source organism: Escherichia coli
Expression system: Not provided
UniProt:
  • Canonical: P08179 (Residues: 1-212; Coverage: 100%)
Gene names: JW2485, b2500, purN
Sequence domains: Formyl transferase
Structure domains: Formyl transferase, N-terminal domain

Ligands and Environments

2 bound ligands:
Ligand GAR 4 x GAR
Ligand DZF 4 x DZF
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 76.7Å b: 72.6Å c: 57Å
α: 111.5° β: 82.8° γ: 62.6°
R-values:
R R work R free
0.25 0.25 not available
Expression system: Not provided

Quick links

Citations

5 review citations

Aminoacyl-tRNA synthesis.
Ibba et al. (2000)
4 more

13 mentions without citation

Structural biology of the purine biosynthetic pathway.
Zhang et al. (2008)
12 more