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NUCLEOTIDE SEQUENCE AND X-RAY STRUCTURE OF CYCLODEXTRIN GLYCOSYLTRANSFERASE FROM BACILLUS CIRCULANS STRAIN 251 IN A MALTOSE-DEPENDENT CRYSTAL FORM

Source organism: Niallia circulans
Biochemical function: starch binding
Biological process: carbohydrate metabolic process
Cellular component: extracellular region

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EC 2.4.1.19: Cyclomaltodextrin glucanotransferase

Reaction catalysed:
Cyclizes part of a (1->4)-alpha-D-glucan chain by formation of a (1->4)-alpha-D-glucosidic bond
Systematic name:
(1->4)-alpha-D-glucan:(1->4)-alpha-D-glucan 4-alpha-D-((1->4)-alpha-D-glucano)-transferase (cyclizing)
Alternative Name(s):
  • 1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)
  • Alpha-1,4-glucan 4-glycosyltransferase, cyclizing
  • Alpha-cyclodextrin glucanotransferase
  • Alpha-cyclodextrin glycosyltransferase
  • BMA
  • Bacillus macerans amylase
  • Beta-cyclodextrin glycosyltransferase
  • CGTase
  • Cyclodextrin glucanotransferase
  • Cyclodextrin glycosyltransferase
  • Cyclomaltodextrin glucotransferase
  • Cyclomaltodextrin glycosyltransferase
  • Gamma-cyclodextrin glycosyltransferase
  • Konchizaimu
  • Neutral-cyclodextrin glycosyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00686
Domain description: Starch binding domain
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of Pfam domain PF00686 (Starch binding domain) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.

PF01833
Domain description: IPT/TIG domain
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of Pfam domain PF01833 (IPT/TIG domain) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.

PF02806
Domain description: Alpha amylase, C-terminal all-beta domain
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of Pfam domain PF02806 (Alpha amylase, C-terminal all-beta domain) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.

PF00128
Domain description: Alpha amylase, catalytic domain
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of Pfam domain PF00128 (Alpha amylase, catalytic domain) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002044
Domain description: Carbohydrate binding module family 20
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR006046
Domain description: Alpha amylase
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR006047
Domain description: Glycosyl hydrolase, family 13, catalytic domain
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR013784
Domain description: Carbohydrate-binding-like fold
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR002909
Domain description: IPT domain
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR006048
Domain description: Alpha-amylase/branching enzyme, C-terminal all beta
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR031319
Domain description: Alpha-amylase, C-terminal domain
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Cyclomaltodextrin glucanotransferase

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Cyclomaltodextrin glucanotransferase. Showing 2 copies in chain A.
2.60.40.1180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Golgi alpha-mannosidase II
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of CATH domain 2.60.40.1180 (Immunoglobulin-like) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.
SCOP SCOP annotations
49453
Class: All beta proteins
Fold: Prealbumin-like
Superfamily: Starch-binding domain-like
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of SCOP domain 49453 (Starch-binding domain) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.
81282
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of SCOP domain 81282 (E-set domains of sugar-utilizing enzymes) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.
51012
Class: All beta proteins
Fold: Glycosyl hydrolase domain
Superfamily: Glycosyl hydrolase domain
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of SCOP domain 51012 (alpha-Amylases, C-terminal beta-sheet domain) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.
51446
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: (Trans)glycosidases
Occurring in:
  1. Cyclomaltodextrin glucanotransferase
The deposited structure of PDB entry 1cdg contains 1 copy of SCOP domain 51446 (Amylase, catalytic domain) in Cyclomaltodextrin glucanotransferase. Showing 1 copy in chain A.

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