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STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-DEOXY-5'-METHYLTHIOADENOSINE AND SULFATE AT 1.7 A RESOLUTION

X-ray diffraction
1.7Å resolution
PDB entry 1cg6 coloured by chain, front view.
PDB entry 1cg6 coloured by chain, side view.
PDB entry 1cg6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: S-methyl-5'-thioadenosine phosphorylase
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Multimeric state: homo trimer
Accessible surface area: 30000.02 Å2
Buried surface area: 9358.59 Å2
Dissociation area: 3,468.93 Å2
Dissociation energy (ΔGdiss): 36.91 kcal/mol
Dissociation entropy (TΔSdiss): 27.3 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-171545

Macromolecules

S-methyl-5'-thioadenosine phosphorylase
Chain: A
Length: 283 amino acids
Theoretical weight: 31.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13126 (Residues: 1-283; Coverage: 100%)
Gene names: MSAP, MTAP
Pfam: Phosphorylase superfamily
InterPro:
CATH: Nucleoside phosphorylase domain
SCOP: Purine and uridine phosphorylases
S-methyl-5'-thioadenosine phosphorylase in PDB entry 1cg6, assembly 1, front view.
S-methyl-5'-thioadenosine phosphorylase in PDB entry 1cg6, assembly 1, side view.
S-methyl-5'-thioadenosine phosphorylase in PDB entry 1cg6, assembly 1, top view.
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