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GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE

X-ray diffraction
3Å resolution
PDB entry 1cj1 coloured by chain, front view.
PDB entry 1cj1 coloured by chain, side view.
PDB entry 1cj1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Growth factor receptor-bound protein 2
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Multimeric state: homo dimer
Accessible surface area: 9212.1 Å2
Buried surface area: 3246.87 Å2
Dissociation area: 838.51 Å2
Dissociation energy (ΔGdiss): 6.6 kcal/mol
Dissociation entropy (TΔSdiss): 11.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158872
Assembly 2
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Assembly Name: Growth factor receptor-bound protein 2
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Multimeric state: homo dimer
Accessible surface area: 9247.16 Å2
Buried surface area: 3227.26 Å2
Dissociation area: 826.91 Å2
Dissociation energy (ΔGdiss): 5.91 kcal/mol
Dissociation entropy (TΔSdiss): 11.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158872
Assembly 3
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Assembly Name: Growth factor receptor-bound protein 2
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Multimeric state: homo dimer
Accessible surface area: 9235.0 Å2
Buried surface area: 3225.03 Å2
Dissociation area: 826.6 Å2
Dissociation energy (ΔGdiss): 5.78 kcal/mol
Dissociation entropy (TΔSdiss): 11.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158872
Assembly 4
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Assembly Name: Growth factor receptor-bound protein 2
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Multimeric state: homo dimer
Accessible surface area: 9195.35 Å2
Buried surface area: 3252.75 Å2
Dissociation area: 843.05 Å2
Dissociation energy (ΔGdiss): 6.94 kcal/mol
Dissociation entropy (TΔSdiss): 11.1 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158872
Assembly 5
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Assembly Name: Growth factor receptor-bound protein 2
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Multimeric state: homo dimer
Accessible surface area: 9215.76 Å2
Buried surface area: 3238.19 Å2
Dissociation area: 835.84 Å2
Dissociation energy (ΔGdiss): 5.53 kcal/mol
Dissociation entropy (TΔSdiss): 11.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158872
Assembly 6
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Assembly Name: Growth factor receptor-bound protein 2
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Multimeric state: homo dimer
Accessible surface area: 9260.65 Å2
Buried surface area: 3199.51 Å2
Dissociation area: 812.18 Å2
Dissociation energy (ΔGdiss): 6.46 kcal/mol
Dissociation entropy (TΔSdiss): 11.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158872

Macromolecules

Growth factor receptor-bound protein 2
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 96 amino acids
Theoretical weight: 11.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 57-152; Coverage: 44%)
Gene names: ASH, GRB2
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain
Growth factor receptor-bound protein 2 in PDB entry 1cj1, assembly 1, front view.
Growth factor receptor-bound protein 2 in PDB entry 1cj1, assembly 1, side view.
Growth factor receptor-bound protein 2 in PDB entry 1cj1, assembly 1, top view.
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