› 1cl3

Solution NMR

MOLECULAR INSIGHTS INTO PEBP2/CBF-SMMHC ASSOCIATED ACUTE LEUKEMIA REVEALED FROM THE THREE-DIMENSIONAL STRUCTURE OF PEBP2/CBF BETA

Released:
DOI: 10.2210/pdb1cl3/pdb
PDB entry 1cl3 coloured by chain, ensemble of 25 models, front view.
PDB entry 1cl3 coloured by chain, ensemble of 25 models, side view.
PDB entry 1cl3 coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta.
Goger M, Gupta V, Kim WY, Shigesada K, Ito Y, Werner MH
Nat Struct Biol 6 620-3 (1999)
PMID: 10404215

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Core-binding factor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 16.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13951 (Residues: 4-141; Coverage: 76%)
Gene name: CBFB
Sequence domains: Core binding factor beta subunit
Structure domains: Core binding factor, beta subunit

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DYNAMICAL SIMULATED ANNEALING
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

Core-binding factors in haematopoiesis and leukaemia.
Speck et al. (2002)
12 more

3 mentions without citation

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta.
Warren et al. (2000)
2 more