› 1csa

Solution NMR

THE MUTANT E.COLI F112W CYCLOPHILIN BINDS CYCLOSPORIN A IN NEARLY IDENTICAL CONFORMATION AS HUMAN CYCLOPHILIN

Released:
DOI: 10.2210/pdb1csa/pdb
PDB entry 1csa coloured by chain, ensemble of 18 models, front view.
PDB entry 1csa coloured by chain, ensemble of 18 models, side view.
PDB entry 1csa coloured by chain, ensemble of 18 models, top view.
Source organism: Tolypocladium inflatum
Primary publication:
The mutant Escherichia coli F112W cyclophilin binds cyclosporin A in nearly identical conformation as human cyclophilin.
Fejzo J, Etzkorn FA, Clubb RT, Shi Y, Walsh CT, Wagner G
Biochemistry 33 5711-20 (1994)
PMID: 8180197

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162140 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CYCLOSPORIN A Chain: A
Molecule details ›
Chain: A
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DAL 1 x DAL
Ligand MLE 4 x MLE
Ligand MVA 1 x MVA
Ligand BMT 1 x BMT
Ligand ABA 1 x ABA
Ligand SAR 1 x SAR

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

2 review citations

Peptidylproline cis/trans isomerases.
Galat et al. (1995)
1 more

2 mentions without citation

Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding.
Bewley et al. (2020)
1 more