› 1cya

Solution NMR

NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING

Released:
DOI: 10.2210/pdb1cya/pdb
PDB entry 1cya coloured by chain, front view.
PDB entry 1cya coloured by chain, side view.
PDB entry 1cya coloured by chain, top view.
Source organism: Tolypocladium inflatum
Primary publication:
NMR studies of [U-13C]cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding.
Fesik SW, Gampe RT, Eaton HL, Gemmecker G, Olejniczak ET, Neri P, Holzman TF, Egan DA, Edalji R, Simmer R
Biochemistry 30 6574-83 (1991)
PMID: 2054356

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162146 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CYCLOSPORIN A Chain: A
Molecule details ›
Chain: A
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DAL 1 x DAL
Ligand MLE 4 x MLE
Ligand MVA 1 x MVA
Ligand BMT 1 x BMT
Ligand ABA 1 x ABA
Ligand SAR 1 x SAR

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

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Citations

16 review citations

The mechanism of action of cyclosporin A and FK506.
Schreiber et al. (1992)
15 more