› 1cyn

X-ray diffraction
1.85Å resolution

CYCLOPHILIN B COMPLEXED WITH [D-(CHOLINYLESTER)SER8]-CYCLOSPORIN

Released:
DOI: 10.2210/pdb1cyn/pdb
PDB entry 1cyn coloured by chain, front view.
PDB entry 1cyn coloured by chain, side view.
PDB entry 1cyn coloured by chain, top view.
Source organisms:
Primary publication:
X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.
Mikol V, Kallen J, Walkinshaw MD
Proc. Natl. Acad. Sci. U.S.A. 91 5183-6 (1994)
PMID: 8197205

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149922 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase B Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23284 (Residues: 39-216; Coverage: 97%)
Gene names: CYPB, PPIB
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
CYCLOSPORIN A Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.24 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DSN 1 x DSN
Ligand MLE 4 x MLE
Ligand MVA 1 x MVA
Ligand BMT 1 x BMT
Ligand ABA 1 x ABA
Ligand SAR 1 x SAR

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 37.46Å b: 46.944Å c: 115.442Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.16 not available
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

The mitochondrial permeability transition pore and its role in cell death.
Crompton M. (1999)
3 more

12 mentions without citation

Identification of HIV inhibitors guided by free energy perturbation calculations.
Acevedo et al. (2012)
11 more