› 1czs

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: COMPLEX WITH PHENYLMERCURY

Released:
DOI: 10.2210/pdb1czs/pdb
PDB entry 1czs coloured by chain, front view.
PDB entry 1czs coloured by chain, side view.
PDB entry 1czs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the membrane-binding C2 domain of human coagulation factor V.
Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH, Fuentes-Prior P
Nature 402 434-9 (1999)
PMID: 10586886

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146103 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coagulation factor V light chain Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 18.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P12259 (Residues: 2065-2224; Coverage: 7%)
Gene name: F5
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

1 bound ligand:
Ligand PHG 1 x PHG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P212121
Unit cell:
a: 46.43Å b: 51.83Å c: 68.15Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.258
Expression system: Not provided

Quick links

Citations

33 review citations

Membrane recognition by phospholipid-binding domains.
Lemmon MA. (2008)
32 more

8 mentions without citation

Molecular pathology of X linked retinoschisis: mutations interfere with retinoschisin secretion and oligomerisation.
Wang et al. (2006)
7 more