› 1d40

X-ray diffraction
1.3Å resolution

BASE SPECIFIC BINDING OF COPPER(II) TO Z-DNA: THE 1.3-ANGSTROMS SINGLE CRYSTAL STRUCTURE OF D(M5CGUAM5CG) IN THE PRESENCE OF CUCL2

Released:
DOI: 10.2210/pdb1d40/pdb
PDB entry 1d40 coloured by chain, front view.
PDB entry 1d40 coloured by chain, side view.
PDB entry 1d40 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Base-specific binding of copper(II) to Z-DNA. The 1.3-A single crystal structure of d(m5CGUAm5CG) in the presence of CuCl2.
Geierstanger BH, Kagawa TF, Chen SL, Quigley GJ, Ho PS
J Biol Chem 266 20185-91 (1991)
PMID: 1939079

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113603 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*(5CM)P*(CU)GP*UP*AP*(5CM)P*(CU)G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.82 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand CU 3 x CU
Ligand CUL 1 x CUL
1 modified residue:
Ligand 5CM 4 x 5CM

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 17.59Å b: 30.58Å c: 44.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 not available not available
Expression system: Not provided

Quick links

Citations

6 review citations

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer.
Wiseman et al. (1996)
5 more

1 mention without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)