Function and Biology Details
Reaction catalysed:
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
homo trimer (preferred)
Assembly name:
Ubiquitin-protein ligase E3A (preferred)
PDBe Complex ID:
PDB-CPX-170128 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin-protein ligase E3A
Molecule details ›
Chains: A, B, C
Length: 358 amino acids
Theoretical weight: 41.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: HECT-domain (ubiquitin-transferase)
Structure domains:
Length: 358 amino acids
Theoretical weight: 41.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q05086 (Residues: 518-875; Coverage: 41%)
Sequence domains: HECT-domain (ubiquitin-transferase)
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU RU200, NSLS BEAMLINE X4A
Spacegroup:
P212121
Expression system: Escherichia coli
