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DIHYDRODIPICOLINATE SYNTHASE

Source organism: Escherichia coli
Biochemical function: identical protein binding
Biological process: small molecule metabolic process
Cellular component: cytosol

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EC 4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase

Reaction catalysed:
Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H(2)O
Systematic name:
L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing; (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate-forming)
Alternative Name(s):
  • DHDPS
  • DapA (gene name)
  • Dihydrodipicolinate synthetase
  • Dihydrodipicolinic acid synthase
  • Dihydropicolinate synthetase
  • L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00701
Domain description: Dihydrodipicolinate synthetase family
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate synthase
The deposited structure of PDB entry 1dhp contains 2 copies of Pfam domain PF00701 (Dihydrodipicolinate synthetase family) in 4-hydroxy-tetrahydrodipicolinate synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002220
Domain description: DapA-like
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate synthase
IPR005263
Domain description: 4-hydroxy-tetrahydrodipicolinate synthase, DapA
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate synthase
IPR020625
Domain description: Schiff base-forming aldolase, active site
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate synthase
IPR020624
Domain description: Schiff base-forming aldolase, conserved site
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate synthase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate synthase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate synthase
The deposited structure of PDB entry 1dhp contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in 4-hydroxy-tetrahydrodipicolinate synthase. Showing 1 copy in chain A.
SCOP SCOP annotation
51570
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Occurring in:
  1. 4-hydroxy-tetrahydrodipicolinate synthase
The deposited structure of PDB entry 1dhp contains 2 copies of SCOP domain 51570 (Class I aldolase) in 4-hydroxy-tetrahydrodipicolinate synthase. Showing 1 copy in chain A.

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