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CRYSTAL STRUCTURE OF THE HUMAN CLASS II MHC PROTEIN HLA-DR1 COMPLEXED WITH AN INFLUENZA VIRUS PEPTIDE

X-ray diffraction
2.8Å resolution
PDB entry 1dlh coloured by chain, front view.
PDB entry 1dlh coloured by chain, side view.
PDB entry 1dlh coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 34262.84 Å2
Buried surface area: 18679.99 Å2
Dissociation area: 3,668.72 Å2
Dissociation energy (ΔGdiss): 23.57 kcal/mol
Dissociation entropy (TΔSdiss): 31.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-135357

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chains: A, D
Length: 180 amino acids
Theoretical weight: 20.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: P01903 (Residues: 28-207; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1dlh, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1dlh, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 1dlh, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chains: B, E
Length: 188 amino acids
Theoretical weight: 21.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: P01911 (Residues: 32-219; Coverage: 79%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1dlh, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1dlh, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 1dlh, assembly 1, top view.
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Hemagglutinin HA1 chain
Chains: C, F
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Influenza A virus (A/England/878/1969(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P04664 (Residues: 306-318; Coverage: 4%)
Gene name: HA
Hemagglutinin HA1 chain in PDB entry 1dlh, assembly 1, front view.
Hemagglutinin HA1 chain in PDB entry 1dlh, assembly 1, side view.
Hemagglutinin HA1 chain in PDB entry 1dlh, assembly 1, top view.
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