› 1don

Solution NMR

SOLUTION STRUCTURE OF THE MONOCYTE CHEMOATTRACTANT PROTEIN-1 DIMER USING HETERONUCLEAR, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1don/pdb
PDB entry 1don coloured by chain, ensemble of 20 models, front view.
PDB entry 1don coloured by chain, ensemble of 20 models, side view.
PDB entry 1don coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer.
Handel TM, Domaille PJ
Biochemistry 35 6569-84 (1996)
PMID: 8639605

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 76 amino acids
Theoretical weight: 8.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13500 (Residues: 24-99; Coverage: 100%)
Gene names: CCL2, MCP1, SCYA2
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Monocyte chemoattractant protein-1 (MCP-1): an overview.
Deshmane et al. (2009)
29 more

6 mentions without citation

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis.
Gschwandtner et al. (2019)
5 more