› 1dpq

Solution NMR

SOLUTION STRUCTURE OF THE CONSTITUTIVELY ACTIVE MUTANT OF THE INTEGRIN ALPHA IIB CYTOPLASMIC DOMAIN.

Released:
DOI: 10.2210/pdb1dpq/pdb
PDB entry 1dpq coloured by chain, ensemble of 11 models, front view.
PDB entry 1dpq coloured by chain, ensemble of 11 models, side view.
PDB entry 1dpq coloured by chain, ensemble of 11 models, top view.
Source organism: Homo sapiens
Primary publication:
A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit.
Vinogradova O, Haas T, Plow EF, Qin J
Proc Natl Acad Sci U S A 97 1450-5 (2000)
PMID: 10677482

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140154 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-IIb light chain, form 2 Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 2.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08514 (Residues: 1020-1039; Coverage: 2%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains: Integrin alpha cytoplasmic region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

25 review citations

The tail of integrins, talin, and kindlins.
Moser et al. (2009)
24 more

2 mentions without citation

A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit.
Vinogradova et al. (2000)
1 more