Assemblies
Assembly Name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Multimeric state:
homo tetramer
Accessible surface area:
46393.21 Å2
Buried surface area:
38160.44 Å2
Dissociation area:
3,506.62
Å2
Dissociation energy (ΔGdiss):
62.04
kcal/mol
Dissociation entropy (TΔSdiss):
15.89
kcal/mol
Symmetry number:
4
PDBe Complex ID:
PDB-CPX-137325
Macromolecules
Chains: A, B, C, D
Length: 467 amino acids
Theoretical weight: 50.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam: Hydroxymethylglutaryl-coenzyme A reductase
InterPro:
Length: 467 amino acids
Theoretical weight: 50.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P04035 (Residues: 425-888; Coverage: 52%)
Pfam: Hydroxymethylglutaryl-coenzyme A reductase
InterPro:
- Hydroxymethylglutaryl-CoA reductase, metazoan
- Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
- Hydroxymethylglutaryl-CoA reductase, class I/II
- Hydroxymethylglutaryl-CoA reductase, N-terminal
- Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
- Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
- Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
- Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
- HMGR, N-terminal domain
- 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
- Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
