› 1du6

Solution NMR

SOLUTION STRUCTURE OF THE TRUNCATED PBX HOMEODOMAIN

Released:
DOI: 10.2210/pdb1du6/pdb
PDB entry 1du6 coloured by chain, ensemble of 30 models, front view.
PDB entry 1du6 coloured by chain, ensemble of 30 models, side view.
PDB entry 1du6 coloured by chain, ensemble of 30 models, top view.
Source organism: Mus musculus
Primary publication:
Conformational changes in the PBX homeodomain and C-terminal extension upon binding DNA and HOX-derived YPWM peptides.
Sprules T, Green N, Featherstone M, Gehring K
Biochemistry 39 9943-50 (2000)
PMID: 10933814

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154428 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pre-B-cell leukemia transcription factor 1 Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.46 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P41778 (Residues: 238-238, 241-294; Coverage: 13%)
Gene names: Pbx-1, Pbx1
Sequence domains: Homeobox KN domain
Structure domains: Homeodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: dynamical annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Hox genes and their candidate downstream targets in the developing central nervous system.
Akin et al. (2005)
1 more

2 mentions without citation

Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.
Zeiske et al. (2018)
1 more