› 1dvn

X-ray diffraction
2.1Å resolution

LATENT FORM OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)

Released:
DOI: 10.2210/pdb1dvn/pdb
PDB entry 1dvn coloured by chain, front view.
PDB entry 1dvn coloured by chain, side view.
PDB entry 1dvn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of active and latent PAI-1: a possible stabilizing role for chloride ions.
Stout TJ, Graham H, Buckley DI, Matthews DJ
Biochemistry 39 8460-9 (2000)
PMID: 10913251

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138523 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 42.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: C2
Unit cell:
a: 154.581Å b: 46.697Å c: 61.966Å
α: 90° β: 107.11° γ: 90°
R-values:
R R work R free
0.213 0.236 0.289
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Serpins in thrombosis, hemostasis and fibrinolysis.
Rau et al. (2007)
6 more

19 mentions without citation

An overview of the serpin superfamily.
Law et al. (2006)
18 more