› 1e17

Solution NMR

Solution structure of the DNA binding domain of the human Forkhead transcription factor AFX (FOXO4)

Released:
DOI: 10.2210/pdb1e17/pdb
PDB entry 1e17 coloured by chain, ensemble of 20 models, front view.
PDB entry 1e17 coloured by chain, ensemble of 20 models, side view.
PDB entry 1e17 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
1H, 13C and 15N resonance assignments of the DNA binding domain of the human forkhead transcription factor AFX.
Weigelt J, Climent I, Dahlman-Wright K, Wikström M
J Biomol NMR 17 181-2 (2000)
PMID: 10921784

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161377 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Forkhead box protein O4 Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 16.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P98177 (Residues: 86-211; Coverage: 25%)
Gene names: AFX, AFX1, FOXO4, MLLT7
Sequence domains: Forkhead domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING IN TORSION ANGLE SPACE
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

DmFoxF, a novel Drosophila fork head factor expressed in visceral mesoderm.
Pérez Sánchez et al. (2002)
2 more

12 mentions without citation

Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations.
Dai et al. (2021)
11 more