› 1e3g

X-ray diffraction
2.4Å resolution

Human Androgen Receptor Ligand Binding in complex with the ligand metribolone (R1881)

Released:
DOI: 10.2210/pdb1e3g/pdb
PDB entry 1e3g coloured by chain, front view.
PDB entry 1e3g coloured by chain, side view.
PDB entry 1e3g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations.
Matias PM, Donner P, Coelho R, Thomaz M, Peixoto C, Macedo S, Otto N, Joschko S, Scholz P, Wegg A, Bäsler S, Schäfer M, Egner U, Carrondo MA
J Biol Chem 275 26164-71 (2000)
PMID: 10840043

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 30.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10275 (Residues: 658-920; Coverage: 29%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand R18 1 x R18
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 54.28Å b: 66.14Å c: 71.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.297
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

88 review citations

The development of androgen-independent prostate cancer.
Feldman et al. (2001)
87 more

42 mentions without citation

Androgen receptor: structure, role in prostate cancer and drug discovery.
Tan et al. (2015)
41 more