› 1eba

X-ray diffraction
2.7Å resolution

COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN INACTIVE PEPTIDE [EMP33] CONTAINS 3,5-DIBROMOTYROSINE IN POSITION 4 (DENOTED DBY)

Released:
DOI: 10.2210/pdb1eba/pdb
PDB entry 1eba coloured by chain, front view.
PDB entry 1eba coloured by chain, side view.
PDB entry 1eba coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.
Livnah O, Johnson DL, Stura EA, Farrell FX, Barbone FP, You Y, Liu KD, Goldsmith MA, He W, Krause CD, Pestka S, Jolliffe LK, Wilson IA
Nat Struct Biol 5 993-1004 (1998)
PMID: 9808045

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148530 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Erythropoietin receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 215 amino acids
Theoretical weight: 23.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19235 (Residues: 34-248; Coverage: 44%)
Gene name: EPOR
Sequence domains:
Structure domains: Immunoglobulins
PROTEIN (EPO MIMETICS PEPTIDE 33) Chains: C, D
Molecule details ›
Chains: C, D
Length: 20 amino acids
Theoretical weight: 2.26 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DBY 2 x DBY

Experiments and Validation Details

Entry percentile scores
Unit cell:
a: 58.89Å b: 75.009Å c: 130.527Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.299
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

35 review citations

Interleukin-10 and related cytokines and receptors.
Pestka et al. (2004)
34 more

5 mentions without citation

Ligand discovery and virtual screening using the program LIDAEUS.
Taylor et al. (2008)
4 more