› › Structure analysis

HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN

X-ray diffraction
2.5Å resolution
PDB entry 1efn coloured by chain, front view.
PDB entry 1efn coloured by chain, side view.
PDB entry 1efn coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Tyrosine-protein kinase Fyn and C-terminal core protein
hide full assembly name
Multimeric state: hetero tetramer
Accessible surface area: 16257.58 Å2
Buried surface area: 3806.05 Å2
Dissociation area: 1,707.85 Å2
Dissociation energy (ΔGdiss): -9.31 kcal/mol
Dissociation entropy (TΔSdiss): 31.91 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136958

Macromolecules

Tyrosine-protein kinase Fyn
Chains: A, C
Length: 59 amino acids
Theoretical weight: 6.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 85-143; Coverage: 11%)
Gene name: FYN
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Tyrosine-protein kinase Fyn in PDB entry 1efn, assembly 1, front view.
Tyrosine-protein kinase Fyn in PDB entry 1efn, assembly 1, side view.
Tyrosine-protein kinase Fyn in PDB entry 1efn, assembly 1, top view.
Molecule details ›

Search similar proteins

C-terminal core protein
Chains: B, D
Length: 152 amino acids
Theoretical weight: 17.81 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P03406 (Residues: 54-205; Coverage: 74%)
Gene name: nef
Pfam: Negative factor, (F-Protein) or Nef
InterPro:
CATH: Nef Regulatory Factor
SCOP: Regulatory factor Nef
C-terminal core protein in PDB entry 1efn, assembly 1, front view.
C-terminal core protein in PDB entry 1efn, assembly 1, side view.
C-terminal core protein in PDB entry 1efn, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links