› 1eg3

X-ray diffraction
2Å resolution

STRUCTURE OF A DYSTROPHIN WW DOMAIN FRAGMENT IN COMPLEX WITH A BETA-DYSTROGLYCAN PEPTIDE

Released:
DOI: 10.2210/pdb1eg3/pdb
PDB entry 1eg3 coloured by chain, front view.
PDB entry 1eg3 coloured by chain, side view.
PDB entry 1eg3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.
Huang X, Poy F, Zhang R, Joachimiak A, Sudol M, Eck MJ
Nat Struct Biol 7 634-8 (2000)
PMID: 10932245

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145866 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dystrophin Chain: A
Molecule details ›
Chain: A
Length: 261 amino acids
Theoretical weight: 29.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11532 (Residues: 3046-3306; Coverage: 7%)
Gene name: DMD
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 49.71Å b: 67.47Å c: 85.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.194 0.257
Expression system: Escherichia coli

Quick links

Citations

40 review citations

Function and genetics of dystrophin and dystrophin-related proteins in muscle.
Blake et al. (2002)
39 more

13 mentions without citation

High-resolution global peptide-protein docking using fragments-based PIPER-FlexPepDock.
Alam et al. (2017)
12 more