› 1emn

Solution NMR

NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, MINIMIZED AVERAGE STRUCTURE

Released:
DOI: 10.2210/pdb1emn/pdb
PDB entry 1emn coloured by chain, front view.
PDB entry 1emn coloured by chain, side view.
PDB entry 1emn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders.
Downing AK, Knott V, Werner JM, Cardy CM, Campbell ID, Handford PA
Cell 85 597-605 (1996)
PMID: 8653794

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152940 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrillin-1 Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 8.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35555 (Residues: 2124-2205; Coverage: 3%)
Gene names: FBN, FBN1
Sequence domains: Calcium-binding EGF domain
Structure domains: Laminin

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

57 review citations

Fibulins: a versatile family of extracellular matrix proteins.
Timpl et al. (2003)
56 more

10 mentions without citation

Improved prediction of critical residues for protein function based on network and phylogenetic analyses.
Thibert et al. (2005)
9 more