› 1et1

X-ray diffraction
0.9Å resolution

CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION

Released:
DOI: 10.2210/pdb1et1/pdb
PDB entry 1et1 coloured by chain, front view.
PDB entry 1et1 coloured by chain, side view.
PDB entry 1et1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.
Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F
J Biol Chem 275 27238-44 (2000)
PMID: 10837469

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134149 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parathyroid hormone Chains: A, B
Molecule details ›
Chains: A, B
Length: 34 amino acids
Theoretical weight: 4.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01270 (Residues: 32-65; Coverage: 38%)
Gene name: PTH
Sequence domains: Parathyroid hormone family

Ligands and Environments

1 bound ligand:
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P65
Unit cell:
a: 30.177Å b: 30.177Å c: 110.435Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.137 0.137 0.14
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Parathyroid hormone and parathyroid hormone-related peptide, and their receptors.
Gensure et al. (2005)
10 more

11 mentions without citation

BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions.
Yang et al. (2013)
10 more