› 1f2l

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF CHEMOKINE DOMAIN OF FRACTALKINE

Released:
DOI: 10.2210/pdb1f2l/pdb
PDB entry 1f2l coloured by chain, front view.
PDB entry 1f2l coloured by chain, side view.
PDB entry 1f2l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement.
Hoover DM, Mizoue LS, Handel TM, Lubkowski J
J Biol Chem 275 23187-93 (2000)
PMID: 10770945

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160268 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Processed fractalkine Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 76 amino acids
Theoretical weight: 8.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78423 (Residues: 25-100; Coverage: 20%)
Gene names: A-152E5.2, CX3CL1, FKN, NTT, SCYD1
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B, null
Spacegroup: P6122
Unit cell:
a: 110.473Å b: 110.473Å c: 123.994Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.238 0.238 0.321
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Heparin-protein interactions.
Capila et al. (2002)
10 more

12 mentions without citation

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function.
Salanga et al. (2011)
11 more