› 1f4o

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF GRANCALCIN WITH BOUND CALCIUM

Released:
DOI: 10.2210/pdb1f4o/pdb
PDB entry 1f4o coloured by chain, front view.
PDB entry 1f4o coloured by chain, side view.
PDB entry 1f4o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human grancalcin, a member of the penta-EF-hand protein family.
Jia J, Han Q, Borregaard N, Lollike K, Cygler M
J Mol Biol 300 1271-81 (2000)
PMID: 10903868

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151260 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Grancalcin Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28676 (Residues: 53-217; Coverage: 76%)
Gene names: GCA, GCL
Sequence domains: EF hand
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: C2
Unit cell:
a: 97.37Å b: 50.32Å c: 77.56Å
α: 90° β: 108.17° γ: 90°
R-values:
R R work R free
0.228 0.228 0.284
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structural basis for diversity of the EF-hand calcium-binding proteins.
Grabarek Z. (2006)
20 other articles

1 mention without citation

Molecular modeling, molecular dynamics simulation, and essential dynamics analysis of grancalcin: An upregulated biomarker in experimental autoimmune encephalomyelitis mice.
Paul et al. (2022)